Veterinary Comparative Hematopathology represents the clinical and research experiences gleaned, as well as the study of many of the cases collected, during 35 years of attempting to better understand and recognize hematopoietic neoplasia. It is appropriate to thank those many colleagues whose names appear in figure legends for their contributions.
This book does not trivialize the importance of hematopoietic neoplasia in animals by presenting them as models of human disease. Rather, this work draws heavily on the major and much more extensive current human literature for information on specific diseases not extant in veterinary publications. The major purpose of this book is to define hematopoietic neoplasms in animals, with comparison to those in humans where reasonable similarities exist to guide classification and understanding. In contrast, those neoplasms now defined in humans that lack a currently recognized animal counterpart are described in the human context and await the identification of a comparable animal neoplasm. This format provides veterinarians with a ready reference to help identify such diseases.
It is increasingly evident that diseases of mammals, particularly neoplasms, have a commonality, with those in humans best studied and understood. Genomic studies in humans and animals have demonstrated a remarkable level of conservation of genes and genetic traits extending across mammalian clades. How then can it be that there are more than 30 defined types of B- and T-cell neoplasms in humans that differ widely in biology and response to therapy, but all of those in dogs can be treated as one disease?
Despite the rapid progress that has occurred in oncology, many of us in diagnostic veterinary medicine have noted with concern that veterinary pathology has been slow to adapt to progress in the field. Veterinary oncologists will not be able to devise therapies for specific types of lymphoma unless and until veterinary pathologists provide them with a current level of diagnostic detail. The initiatives of the American College of Veterinary Pathologists in a variety of areas of animal oncology, including canine lymphomas, are timely and needed. This book provides both pathologists and oncologists with information to provide more specificity in both diagnosis and therapy of animal hematopoietic neoplasms.The last revision of the WHO system of classifying human hematopoietic neoplasia, now in use for more than a decade, represents both a challenge and an opportunity for veterinary medicine. The major premise of the current WHO revision was that neoplasms were to be defined as diseases based on all available information rather than on cellular criteria. In the late 1990s, while updating the WHO Fascicle on histology of animal hematopoietic neoplasms, we found that the WHO system of hematopoietic disease classification in humans was readily applicable in animals. The utility of this system is immediately apparent. As new criteria define new entities they are added to the list of neoplasms based on characteristics that permit them to be reliably identified.
This approach is readily applicable to any species and particularly to those domestic animals in which most frequently encounter hematopoietic neoplasia. To that end, this first edition of Veterinary Comparative Hematopathology is based on the WHO classification framework on which future developments can logically be added. This textbook follows the philosophy of a noted fellow countryman, William Osler, who recognized that basic phenomena are common to diseases of all species; there is only one medicine.
Contents
1 The Evolution of Classification Systems for Hematopoietic Neoplasms
2 Normal and Benign Reactive Hematopoietic Tissues
3 B-Cell Neoplasms
4 T-Cell and NK-Cell Neoplasms
5 Acute Myeloid Leukemias
6 Chronic Myeloproliferative Diseases
7 Myeloproliferative/Myelodysplastic Diseases
8 Myelodysplastic Syndromes
9 Hodgkin’s Lymphoma
10 Histiocytoses
Index
Product Details
- Author: Victor E. Valli
- Hardcover: 576 pages
- Publisher: Wiley-Blackwell; 1 edition (October 2, 2007)
- Language: English
- ISBN-10: 081380924X
- ISBN-13: 978-0813809243
- Product Dimensions: 11.2 x 8.6 x 1.3 inches